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Molecular Functional Imaging Lab (MFIL)

Publications

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Research and Review Articles [2017 onward]

  • Asifkhan Shanavas, Kritika Sood, Purvi Mathur, Sulagna Rath, Pranjali Yadav, Navneet Kaur, Priyanka Sharma, Mimansa, Deepak Singh Chauhan, Sonalika Vaidya, Rohit Srivastava, and Abhijit De. 2024. Plasmonic semi shells derived from simultaneous in situ gold growth and anisotropic acid etching of ZIF-8 for photothermal ablation of metastatic breast tumor. Communications Chemistry.

  • Pratham Phadte; Aniketh Bishnu; Pranay Dey; Manikandan M; Megha Mehrotra; Prerna Singh; Shritama Chakrabarty; Rounak Majumdar; Bharat Rekhi; Malay Patra; Abhijit De; Pritha Ray. 2024. Autophagy-mediated ID1 turnover dictates chemo-resistant fate in Ovarian Cancer Stem Cells. Journal of Experimental & Clinical Cancer Research 43(1):222. PMID: 39123206

  • Mujawar, Aaiyas, Dimri, Shalini, Palkina, Ksenia A., Markina, Nadezhda M., Sarkisyan, Karen S., Balakireva, Anastasia V., Yampolsky, Ilia V. and De, Abhijit. 2024. Novel BRET combination for detection of rapamycin-induced protein dimerization using luciferase from fungus Neonothopanus nambi. Heliyon 10(4):e25553. PMID: 38384550

  • UA Shinde, A De, RD Godse, M Rathod, R Thorat, N Sharma, M Ansari. 2024.Efficacy evaluation of carboplatin-etoposide Co-loaded PLGA microparticles for subconjunctival chemotherapy in retinoblastoma. Journal of Drug Delivery Science and Technology, 92: 105333.

  • P Bathla, A Mujawar, A De, BS Sandanaraj. 2024. Development of Noninvasive Activity-Based Protein Profiling-Bioluminescence Resonance Energy Transfer Platform Technology Enables Target Engagement Studies with Absolute . ACS Pharmacology & Translational Science 4;7(2):375-383. PMID: 38357276

  • M Joshi, P Dey, A De. 2023. Recent advancements in targeted protein knockdown technologies—emerging paradigms for targeted therapy. Exploration of Targeted Anti-tumor Therapy 4 (6), 1227.

  • Gayathri Ravichandran, Dinesh Harijan, Nagarajan Ganapathy, Ganesan Prabusankar, Abhijit De, Aravind Rengan. 2023. The multifaceted role of degradable cobalt nanoparticles: dual-target starvation and intracellular acidification engendering LC3-associated whole-cell autophagy. ACS Materials Letters, 5 (10), 2726–2738

  • Mujawar, Aaiyas, Phadte P, Palkina KA, Markina NM, Mohammad A, Thakur BL, Sarkisyan KS, Balakireva AV, Ray P, Yampolsky I, De A. 2023. Triple Reporter Assay: A Non-Overlapping Luciferase Assay for the Measurement of Complex Macromolecular Regulation in Cancer Cells Using a New Mushroom Luciferase–Luciferin Pair. Sensors 23.17:7313. PMID: 37687774

  • Pranay Dey, Nikhil Gadewal, and Abhijit De. 2023. Pathogenic HER3 dimerization domain mutations create a structural bias towards un-conventional EGFR-HER3 signalling axis in breast cancer. International Journal of Biological Macromolecules 242 (pt 2):124765. PMID: 37156315

  • Barkha Singh, Chetna Patnaik, Mayuri Gandhi, Abhijit De and Rohit Srivastava. 2023. Synthesis and degradation mechanism of renally excretable gold core-shell nanoparticles for combined photothermal and photodynamic therapy. Nanoscale. 15(3):1273-1288. PMID: 36541678

  • Pranay Dey, Mansi Joshi, Aaiyas Mujawar, Renu Malhotra and Abhijit De. 2022. Direct knockdown of phospho-PTM targets mediated by TRIM21 can improve personalized treatment in breast cancer. Cellular Oncology, 45(5):873-891. PMID: 35834098

  • Sumit K Mishra, Ajit C Dhadve, Arijit Mal, B. Pradeep K. Reddy, Arti Hole, Murali Krishna Chilakapati, Pritha Ray, Rohit Srivastava, and Abhijit De. 2022. Photothermal Therapy (PTT) is an effective treatment measure against solid tumors which fails to respond conventional chemo/radiation therapies in clinic. Biomaterials Advances. 143: 213153. PMID: 36343390

  • Arijit Mal, Prabhuraj R. S, Renu Malhotra, Snehal K. Valvi, Arvind Ingle, Rohit Srivastava, Abhijit De and Rajdip Bandyopadhyaya. 2022. pH-responsive Sustained Delivery of Doxorubicin Using Aminated and PEGylated Mesoporous Silica Nanoparticles Leads to Enhanced Antitumor Efficacy in Pre-clinical Orthotopic Breast Cancer Model. Journal of Drug Delivery Science and Technology, 77: 103800.

  • Shitaljit K.Sharma, Swathi M Raju, Suhas Phapale, Snehal Valvi, Akhil Dubey, Dibakar Goswami, Debes Ray, Abhijit De, Prasad Phadnis, Vinod Aswal, Rajesh Vatsa, Haladhar Dev Sarma. 2022. Multimodel applications of zinc gallate based persistent luminescent nanoparticles in cancer treatment: Tumor margining, diagnosis and boron neutron capture therapy. ACS Applied Bio Materials. 5(7):3134-3145. PMID: 35758411

  • Aishwarya Shetty, Sumit K Mishra, Abhijit De, Sudeshna Chandra. 2022. Smart releasing CuS/ZnS nanocomposite dual drug carrier and photothermal agent for use as a theranostic tool for cancer therapy.  Journal of Drug Delivery Science and Technology. 70: 103252.

  • Ashish Jha, Gayathri Ravichandran, Abhijit De and Rohit Srivastava. 2022. NANOTORRID®: Graphene‑like properties of a gold/polypropylene nanocomposite and its photothermal application. J Materials Research. DOI: 10.1557/s43578-022-00518-0.

  • Sumit K Mishra, Arti Hole, Reddy BPK, Srivastava R, CM Krishna, Abhijit De. 2021. Raman Micro-spectroscopic Map estimating in vivo precision of tumor ablative effect achieved by photothermal therapy procedure. Nanomedicine: Nanotechnology, Biology, and Medicine. 37:102437. PMID: 34273597

  • Bishnu A, Mehrotra M, Dhadve A, Dimri S, De A, Ray P. 2021. Predicting response to platinum and non-platinum drugs through Bioluminescence Resonance Energy Transfer (BRET) based bio-molecular interactions in platinum resistant Epithelial Ovarian Cancer. Translational Oncology. 14(11): 101193. PMID: 34365218

  • Deo A N, Thorat R, Dhadve A C, De A, Rekhi B, Ray P. 2021. IGF1R-α6 integrin-S100A4 network governs the organ-specific metastasis of chemo resistant epithelial ovarian cancer cells. BBA-Molecular Basis of Disease. 1868(1): 166282. PMID: 34600083

  • Godse R, Rathod M, De A, Shinde U. 2021. Intravitreal Galactose Conjugated Polymeric Nanoparticles of Etoposide for Retinoblastoma. Journal of Drug Delivery Science and Technology. 61:102259.

  • Sharma SK, Raju SM, Goswami D, De A, Phadnis P, Vatsa R. 2021. pH-(low)-insertion peptide assisted detection and diagnosis of cancer using zinc gallate based persistent luminescence nanoparticles. ACS Applied Bio Materials. 4(1): 742−751.

  • Mal Arijit, Bukhari Amirali B, Singh Ram K, Kapoor Aastha, Barai Amlan, Deshpande Ishan, Wadasadawala Tabassum, Ray Pritha, Sen Shamik and De Abhijit. 2021. EpCAM Mediated Cellular Plasticity Promotes Radiation Resistance and Metastasis in Breast Cancer. Frontiers in Cell and Developmental Biology-Molecular and Cellular Oncology. 8:597673. PMID: 33490064.

  • Mhatre O, Reddy BP, Patnaik C, Chakrabarty S, Ingle A, De A, Srivastava R. 2021. pH-Responsive Delivery of Anti-Metastatic Niclosamide Using Mussel Inspired Polydopamine Nanoparticles. International Journal of Pharmaceutics. 597: 120278. PMID: 33540007

  • Dhadve AC, Hari K, Rekhi B, Jolly MK, De A, Ray P. 2020. Decoding molecular interplay between RUNX1 and FOXO3a underlying the pulsatile IGF1R expression during acquirement of chemoresistance. BBA-Molecular Basis of Disease, 1866(6):165754. PMID: 32142859

  • Reddy B P K, Mishra S K, Ravichandran G, Chauhan D S, Srivastava R, De A. 2020. Preclinical evaluation of multi stimuli responsive core-plasmonic nanoshell for photo-triggered tumor ablation: A disintegrable nanohybrid. Applied Materials Today 20:100684.

  • Prabhuraj R S, Arijit Mal, Snehal Valvi, Rohit Srivastava, Abhijit De, Rajdip Bandyopadhyaya. 2020. Non-invasive preclinical evaluation of targeted nanoparticles for the delivery of curcumin in treating pancreatic cancer. ACS Applied Bio Materials. 3 (7), 4643-4654. PMID: 35025463

  • Rathod M, Kelkar M, Valvi S, Salve G, De A. 2020. FOXA1 regulation turns benzamide HDACi treatment effect specific in breast cancerpromoting NIS gene mediated targeted radioiodine therapy. Molecular Therapy: Oncolytics, 19:93-104. PMID: 33102692

  • Jain, N; Dimri, S; Prasad, R; Ravichandran, G; Naidu, V; De, A; Srivastava, R. 2020. Characteristics of molecularly engineered anticancer drug conjugated organic nanomicelles for site-selective cancer cell rupture and growth inhibition of tumor spheroids. ACS Applied Bio Materials, 3(10):7067–79. PMID: 35019366

  • Dimri S, Malhotra R, Shet T, Mokal S, Gupta S, De A. 2020. Noncanonical pS727 post translational modification dictates major STAT3 activation and downstream functions in breast cancer. Experimental Cell Research. 396(2): 112313. PMID: 33002501

  • Mal A, Dey P, Hayes RM, McCarthy JV, Ray A, De A. 2020. In silico identification of potential phosphorylation in the cytoplasmic domain of EpCAM. ACS Omega. 5 (48), 30808-30816. PMID: 33324790

  • Laxman K, Reddy BPK, Mishra SK, Gopal MB, Robinson A, De A, Srivastava R, Ravikanth M. 2020. BF2-Oxasmaragdyrin Nanoparticles: A Non-toxic, Photostable, Enhanced Non-radiative Decay-Assisted Efficient Photothermal Cancer Theragnostic Agent. ACS Appl. Mater. Interfaces. 12(47): 52329-52342. PMID: 33170618

  • Laxman K, Reddy PK, Mishra SK, Robinson A, De A, Srivastava R, Ravikanth M. 2020. Bioinspired carrier-free peptide conjugated BF2-oxasmaragdyrin dye-based nano self-assemblies: a photostable NIR cancer theragnostic agent. NPG Asia Materials. 12: 75.

  • Dey, P, Rathod, M and De A. 2019. Targeting stem cells in the realm of drug resistant breast cancer. Breast Cancer, 11:115-135. PMID: 30881110. [Invited review]

  • Chauhan DS, Reddy BP, Mishra S, Prasad R, Dhanka M, Vats M, Ravichandran G, Poojari D, Mhatre O, De A, and Srivastava R. 2019. A Comprehensive evaluation of degradable and cost effective plasmonic nanoshells for localized photothermolysis of cancer cells. Langmuir 35 (24): 7805-7815. PMID: 31090425

  • Rathod M, Chatterjee S, Dutta S, Kalraiya R, Bhattacharya D, De A. 2019. Mannose glycosylation is an integral step for NIS localization and function in human breast cancer cells. J. Cell Sci. 132, 232058. PMID: 31455607

  • Dimri S, Arora R, Jasani A, De A. 2019. Dynamic monitoring of STAT3 activation in live cells using a novel STAT3 Phospho-BRET sensor. Am. J Nucl. Med. Mol. Imaging 9(6): 321-334. PMID: 31976162

  • Desai S, Barai A, Bukhari AB, De A, Sen S. 2018. α-Actinin-4 confers radioresistance coupled invasiveness in breast cancer cells through AKT pathway. Biochim Biophys Acta – Molecular Cell Research, 1865(1): 196-208. PMID:29055790

  • Shanavas A, Rengan AK, Chauhan D, George L, Vats M, Samra NK, Yadav P, Mathur P, Chakraborty S, Appidi T, De A, Srivastava R. 2018. Glycol chitosan assisted in situ reduction of gold on polymeric template for anti-cancer theranostics. International Journal of Biological Macromolecules. PMID:29174361

  • Kapoor A, Barai A, Thakur B, Das A, Patwardhan SR, Monterio M, Gaikwad S, Bukhari AB, Mogha P, Majumder A, De A, Ray P, Sen S. 2018. Soft drug-resistant ovarian cancer cells migrate via two distinct mechanisms utilizing myosin II-based contractility. Biochim Biophys Acta – Molecular Cell Research, 1865(2): 392-405. PMID:29175377

  • Deepak Chauhan, P Arunkumar, Rajendra Prasad, Sumit K. Mishra, B. Pradeep K. Reddy, Abhijit De, Rohit Srivastava. 2018. Facile synthesis of plasmonic zein nanoshells for imaging-guided photothermal cancer therapy. Materials Science & Engineering C. 90:539-548. PMID: 29858783

  • Chauhan DS, Kumawat MK, Prasad R, Reddy PK, Dhanka M, Mishra SK, Bahadur R, Neekhra S, De A, Srivastava R. 2018. Plasmonic carbon nanohybrids for repetitive and highly localized photothermal cancer therapy. Colloids Surf B Biointerfaces. 172: 430-439. PMID: 30196228

  • Agrawal S, Kelkar M, De A, Kulkarni AR, Gandhi MN. 2018. Newly emerging mesoporous strontium hydroxyapatite nanorods: microwave synthesis and relevance as doxorubicin nanocarrier. J Nanopart Res. 20(9), 1-11.

  • Chauhan DS, Bukhari AB, Ravichandran G, Gupta R, George L, Poojari R, Ingle A, Rengan AK, Shanavas A, Srivastava R, De A. 2018. Enhanced EPR directed and imaging guided photothermal therapy using vitamin E modified Toco-Photoxil. Scientific Reports. 8(1):16673. PMID: 30420735

  • Kelkar MG, Thakur B, Derle A, Chatterjee S, Ray P, De A. 2017. Tumor suppressor protein p53 exerts negative transcriptional regulation on human sodium iodide symporter gene expression in breast cancer. Breast Cancer Res Treat. 164(3): 603-615. PMID:28528452

  • Chauhan DS, Indulekha S, Gottipalli R, Reddy BPK, Chikate TR, Gupta R, Jahagirdar DN, Prasad R, De A, Srivastava R. 2017. NIR light triggered shrinkable thermoresponsive PNVCL nanoshells for cancer theranostics. RSC Advances, 7(70): 44026–34.

  • Dimri, S, Sukanya and De A. 2017. Approaching non-canonical STAT3 signaling to redefine cancer therapeutic strategy. Integr. Mol. Med., 4(1): 1-10. [Invited review]

  • Vats, M, Mishra, S.K, Baghini, M.S, Chauhan, D.S, Srivastava, R, De, A. 2017. Near infrared fluorescence imaging in nano-therapeutics and photo-thermal evaluation. Int. J. Mol. Sci., 18, 924:1-19. PMID: 28452928. [Invited review]

Book Chapters Contributed [2017-2022]

  • Caroline Coleman-Vaughan, Arijit Mal, Abhijit De and Justin V. McCarthy. 2017. The gamma-Secretase Protease Complexes in Neurodegeneration, Cancer and Immunity. In: Pathophysiological Aspects of Proteases. Chakraborti S, Dhalla N (Eds). Springer Nature, Singapore. Chapter 3, Pp. 1-41. [Invited chapter]

  • Rathod Maitreyi, Arijit Mal, Abhijit De. 2018. Reporter-Based BRET Sensors for Measuring Biological Functions In Vivo. In: Reporter Gene Imaging: Methods and Protocols. Methods in Molecular Biology: Dubey P (Ed.). New York: Humana Press, Volume 1790: Pp. 51-74. PMID:29858783 [Invited chapter]

  • Mujawar Aaiyas and Abhijit De. 2022. In-vivo assessment of Protein-Protein Interactions using BRET Assay. In: Reporter Gene Imaging: Bioluminescence: Methods and Protocols, 4th edition. Methods in Molecular Biology: Sung-Bae Kim (Ed.). New York: Humana Press, 2525:239-257. PMID: 35836073 [Invited chapter]

  • Abhijit De. 2023. Bioluminescence. Encyclopedia of Life Sciences, Wiley. https://doi.org/10.1002/9780470015902.a0001412.pub2

Patents

Patent Granted

  1. 2005   US patent: BIOLUMINESCENCE RESONANCE ENERGY TRANSFER (BRET) SYSTEMS AND METHODS OF USE THEREOF. Patent No. US-7842469; 2010.

  2. 2015   Indian patent: “PHOTO-DISINTEGRABLE, NEAR-INFRA RED RESPONSIVE GOLD COATED POLY-(LACTIC-CO-GLYCOLIC ACID) NANOSTRUCTURES AND A PROCESS FOR ITS PREPARATION”. Patent no. 354678; Dt. 29-12-2020.

  3. 2015  Indian patent application filed on “DEGRADABLE OR TRANSFORMABLE GOLD COATED LIPOSOMAL NANO-CONSTRUCT AND A PROCESS FOR ITS PREPARATION”. Patent no. 437191; Dt. 04-07-2023

  4. 2016   Indian patent: “NEAR INFRA-RED RESPONSIVE THERMOSENSITIVE NANOSHELLS AND PROCESS FOR MAKING THE SAME”. Patent no. 377864 Dt. 27-09-2021

  5. 2019   Indian patent: “CONJUGATES OF BF2-OXA_SMARAGDYRIN”. Patent no. 397740; Dt. 26-05-2022.

  6. 2020    Indian Patent application filed on “SELF-ASSEMBLED NICLOSAMIDE-HYALURONIC ACID CONJUGATE MICELLES FOR SITE-SELECTIVE REGRESSION OF TUMOR AND TUMOR SPHEROIDS: SYNTHESIS AND APPLICATIONS THEREOF”. Patent no. 429445; Dt. 20-04-2020.

  7. 2021   Indian Patent application filed on “ASSAY FOR DETERMINING TARGET ENHANCEMENT IN REAL TIME”. Patent no. 421037; Dt. 19-03-2021

  8. 2021    Indian Patent application filed on “NEAR INFRA-RED LIGHT RESPONSIVE GOLD DECORATED SOLID LIPID NANOPARTICLES AND PROCESS FOR PREPARATION THEREOF”. Patent no. 435844; Dt. 27-06-2023.

 

 

Patent filed

  1. 2019    Indian Patent application filed on “A METHOD FOR DETECTION OF PROTEIN ACTIVATION USING PHOSPHO-BRET IMAGING SENSOR AND METHODS THEREOF”. [Ref. no. 201921010208, March 15, 2019]

  2. 2019    Indian Patent application filed on “SYNTHESIS OF MESO-TRITOLYL-BF2-OXASMARAGDYRIN BASED QUANTUM DOTS”. [Ref. no. 201921040093, October 03, 2019]

  3. 2020    Indian Patent application filed on “PEPTIDE TARGET FOR PLATINUM DRUG RESISTANT OVARIAN CANCER”. [Ref. no. 202021034662, August 12, 2020].

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